Ribosomal frameshift

A ribosomal frameshift allows alternative translation of a mRNA sequence by changing the open reading frame. It is commonly found in viruses including barley yellow dwarf virus[1], potato leafroll virus[2] and simian retrovirus-1[3]. Ribosomal frameshifting is promoted by a pseudoknot structure and slippery sequence (usually UUUAAAC)[4]. It is often required for translation of putative RNA-dependent RNA polymerase.

See also

Gallery of secondary structure images
RF_site1: Secondary structure taken from the Rfam database. Family RF01074. Derived from Pseudobase PKB00046PKB00044PKB00240  
RF_site2: Secondary structure taken from the Rfam database. Family RF01076. Derived from Pseudobase PKB00218PKB00233  
RF_site3: Secondary structure taken from the Rfam database. Family RF01079. Derived from Pseudobase PKB00042PKB00043  
RF_site4: Secondary structure taken from the Rfam database. Family RF01090. Derived from Pseudobase PKB00257  
RF_site5: Secondary structure taken from the Rfam database. Family RF01093. Derived from Pseudobase PKB00258  
RF_site6: Secondary structure taken from the Rfam database. Family RF01094. Derived from Pseudobase PKB00128  
RF_site8: Secondary structure taken from the Rfam database. Family RF01097. Derived from Pseudobase PKB00107  
RF_site9: Secondary structure taken from the Rfam database. Family RF01098. Derived from Pseudobase PKB00080  

References

  1. ^ Vincent JR, Lister RM, Larkins BA (October 1991). "Nucleotide sequence analysis and genomic organization of the NY-RPV isolate of barley yellow dwarf virus". J. Gen. Virol. 72 ( Pt 10): 2347–55. PMID 1840612. http://vir.sgmjournals.org/cgi/pmidlookup?view=long&pmid=1840612. 
  2. ^ Kujawa AB, Drugeon G, Hulanicka D, Haenni AL (May 1993). "Structural requirements for efficient translational frameshifting in the synthesis of the putative viral RNA-dependent RNA polymerase of potato leafroll virus". Nucleic Acids Res. 21 (9): 2165–71. doi:10.1093/nar/21.9.2165. PMC 309480. PMID 8502558. http://nar.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=8502558. 
  3. ^ Sung D, Kang H (March 1998). "Mutational analysis of the RNA pseudoknot involved in efficient ribosomal frameshifting in simian retrovirus-1". Nucleic Acids Res. 26 (6): 1369–72. doi:10.1093/nar/26.6.1369. PMC 147434. PMID 9490779. http://nar.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=9490779. 
  4. ^ Meulenberg JJ, Hulst MM, de Meijer EJ, et al. (January 1993). "Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV". Virology 192 (1): 62–72. doi:10.1006/viro.1993.1008. PMID 8517032. 

External links

Pseudobase

Recode